Hello Friends , here is the next video in the learning pharmacy series.... In this video , we have discussed about General Anesthetics In Brief Watch the video till the end to get complete information regarding pharmacokinetics of drugs.
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Topic discussed in the video :-
Pharmacokinetics - the branch of pharmacology concerned with the movement of drugs within the body, the time course of its absorption, bioavailability, distribution, metabolism, and excretion or sometimes described as what the body does to a drug.
It include four steps:- Absorption, Distribution, Metabolism, Excretion.
1-Absorption - the process of a substance entering the blood circulation.
2-Distribution - the dispersion or dissemination of substances throughout the fluids and tissues of the body.
3-Metabolism (or biotransformation, or inactivation) – the recognition by the organism that a foreign substance is present and the irreversible transformation of parent compounds into daughter metabolites.
4-Excretion - the removal of the substances from the body. In rare cases, some drugs irreversibly accumulate in body tissue.
Volume of distribution is the The apparent volume in which a drug is distributed after reaches to equilibrium.
Bio availability-The systemically available fraction of a drug.
Half life-This is the period of time required for the concentration or amount of drug in the body to be reduced by one-half..
Loading dose-A loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose.
Factors Affecting Absorption-
PH, Area of absorbing Surface, Presence of other Substances
Factor affecting distribution-Lipophilicity, Blood flow, Capillary Permeability, Plasma & Tissue Binding, Volume of distribution(Vd)
Passive diffusion-Movement from higher to lower concentration.
Facilitated diffusion-Movement from higher to lower via career protein.
Active diffusion-Energy dependent diffusion.
Endocytosis-Engulfment of larger molecules by cell.
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Dream Culture by Kevin MacLeod is licensed under a Creative Commons Attribution licence (
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